TUB (gene)

Tubby homolog (mouse)

PDB rendering based on 1c8z.

Available structures
PDB	1c8z, 1i7e, 1s31

Identifiers

Symbols

TUB; rd5

External IDs

OMIM: 601197 MGI: 2651573 HomoloGene: 31147 GeneCards: TUB Gene

Gene Ontology
Cellular component	• extracellular region • nucleus • cytoplasm • plasma membrane • intracellular membrane-bounded organelle
Biological process	• positive regulation of phagocytosis • response to stimulus
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 11:
8.04 – 8.13 Mb

Chr 7:
116.09 – 116.18 Mb

PubMed search

[1]

[2]

Tubby protein homolog is a protein that in humans is encoded by the TUB gene.^[1]^[2]

This gene encodes a member of the Tubby family of bipartite transcription factors. The encoded protein may play a role in obesity and sensorineural degradation. The crystal structure has been determined for a similar protein in mouse, and it functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis. Two transcript variants encoding distinct isoforms have been identified for this gene.^[2]

Interactions

TUB (gene) has been shown to interact with PLCG1.^[3]

References

^ Kleyn PW, Fan W, Kovats SG, Lee JJ, Pulido JC, Wu Y, Berkemeier LR, Misumi DJ, Holmgren L, Charlat O, Woolf EA, Tayber O, Brody T, Shu P, Hawkins F, Kennedy B, Baldini L, Ebeling C, Alperin GD, Deeds J, Lakey ND, Culpepper J, Chen H, Glucksmann-Kuis MA, Carlson GA, Duyk GM, Moore KJ (Jun 1996). "Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family". Cell 85 (2): 281–90. doi:10.1016/S0092-8674(00)81104-6. PMID 8612280.
^ ^a ^b "Entrez Gene: TUB tubby homolog (mouse)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7275.
^ Kapeller, R; Moriarty A, Strauss A, Stubdal H, Theriault K, Siebert E, Chickering T, Morgenstern J P, Tartaglia L A, Lillie J (Aug. 1999). "Tyrosine phosphorylation of tub and its association with Src homology 2 domain-containing proteins implicate tub in intracellular signaling by insulin". J. Biol. Chem. (UNITED STATES) 274 (35): 24980–6. doi:10.1074/jbc.274.35.24980. ISSN 0021-9258. PMID 10455176.

Ikeda A, Nishina PM, Naggert JK (2002). "The tubby-like proteins, a family with roles in neuronal development and function.". J. Cell. Sci. 115 (Pt 1): 9–14. PMID 11801719.
Jones JM, Meisler MH, Seldin MF, et al. (1992). "Localization of insulin-2 (Ins-2) and the obesity mutant tubby (tub) to distinct regions of mouse chromosome 7.". Genomics 14 (1): 197–9. doi:10.1016/S0888-7543(05)80308-8. PMID 1358794.
North MA, Naggert JK, Yan Y, et al. (1997). "Molecular characterization of TUB, TULP1, and TULP2, members of the novel tubby gene family and their possible relation to ocular diseases.". Proc. Natl. Acad. Sci. U.S.A. 94 (7): 3128–33. doi:10.1073/pnas.94.7.3128. PMC 20333. PMID 9096357. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=20333.
Kapeller R, Moriarty A, Strauss A, et al. (1999). "Tyrosine phosphorylation of tub and its association with Src homology 2 domain-containing proteins implicate tub in intracellular signaling by insulin.". J. Biol. Chem. 274 (35): 24980–6. doi:10.1074/jbc.274.35.24980. PMID 10455176.
Boggon TJ, Shan WS, Santagata S, et al. (1999). "Implication of tubby proteins as transcription factors by structure-based functional analysis.". Science 286 (5447): 2119–25. doi:10.1126/science.286.5447.2119. PMID 10591637.
He W, Ikeda S, Bronson RT, et al. (2001). "GFP-tagged expression and immunohistochemical studies to determine the subcellular localization of the tubby gene family members.". Brain Res. Mol. Brain Res. 81 (1-2): 109–17. doi:10.1016/S0169-328X(00)00164-9. PMID 11000483.
Santagata S, Boggon TJ, Baird CL, et al. (2001). "G-protein signaling through tubby proteins.". Science 292 (5524): 2041–50. doi:10.1126/science.1061233. PMID 11375483.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Shiri-Sverdlov R, Custers A, van Vliet-Ostaptchouk JV, et al. (2006). "Identification of TUB as a novel candidate gene influencing body weight in humans.". Diabetes 55 (2): 385–9. doi:10.2337/diabetes.55.02.06.db05-0997. PMID 16443771.
Giannaccini G, Giusti L, Santini F, et al. (2007). "Tubby protein in human lymphocytes from normal weight and obese subjects.". Clin. Biochem. 40 (11): 806–9. doi:10.1016/j.clinbiochem.2007.03.020. PMID 17498679.

PDB gallery

1c8z: C-TERMINAL DOMAIN OF MOUSE BRAIN TUBBY PROTEIN

1i7e: C-Terminal Domain Of Mouse Brain Tubby Protein bound to Phosphatidylinositol 4,5-bis-phosphate

1s31: Crystal Structure Analysis of the human Tub protein (isoform a) spanning residues 289 through 561

TUB (gene)

Interactions

References

Further reading